Successful transition to option period 1. HDTRA1-12-D-0003-0002 Novel delivery systems for protective antigens of Burkholderia. The project consortia have successfully delivered results from the base period to enable the programme to transition to a second year with support from DTRA (Defence Threat Reduction Agency). This project is exploring the use of Virus Like Particles (VLP) to increase the immunogenicity of carbohydrate antigens derived from Burkholderia, a target organism on the biological warfare agents list. These challenging yet critical antigens require assistance in raising sufficient T-cell mediated responses and thus lasting immune protection. For a vaccine to work well, this dynamic must be shifted, hence the focus on VLP’s. (I will try and look out an image for Monday).