SEPSIS

Sepsis Research and Quick Test Assays.

CDC’s National Center for Health Statistics estimates that cases of patients treated in hospital with sepsis increased from 621,000 in the year 2000 to 1,141,000 in 2008.

A fatality rate of between 28 and 50 percent is expected of patients who develop sepsis..

Common symptoms of sepsis are fever, chills, rapid breathing and heart rate, rash, confusion, and disorientation.Thermometer1
Many of these symptoms, such as fever and difficulty breathing, are the same as symptoms for other conditions, this makes sepsis very hard to diagnose in its early stages.

People with sepsis are usually treated in hospital intensive care units.
Doctors treat the underlying infection, with antibiotics and help to sustain the vital organs. This is to prevent a rapid drop in blood pressure, which leads to septic shock.

So early diagnosis is vital to getting the right treatment to the patient as soon as possible.

Other types of treatment, such as mechanical ventilation or kidney dialysis, may sometimes be necessary.
Surgery is sometimes required to clear a local site of infection.

Many other drugs, including vasopressors and corticosteroids, may be used to treat sepsis or to revive those who have gone into septic shock.

SepsisProgressSepsis is a clinical syndrome defined by the presence of both infection and a systemic inflammatory response (SIRS)

Many survivors of severe sepsis recover completely and return to normal.
Some patients, especially those who had pre-existing chronic diseases, may experience permanent organ damage. For example, someone who already has kidney impairment, sepsis can lead to kidney failure. This means that they will require lifelong dialysis treatment. So having a test that can quickly diagnose and help prevent the onset of sepsis is vital.

Our Sepsis Assay.

Our many years of scientific research has led us to make significant advances in understanding the process of Sepsis and how it may be identified in patients in two different scenarios:

  • Sepsis in Accident & Emergency wards.
  • Monitoring post-operative patients.

Traditional methods use blood cultures to be tested in the laboratory and it can take 2 -3 days for the result to be known.

In many cases this would be too late to save a patient as once sepsis sets in, their condition goes down extremely rapidly.

The assay developed by Mologic would be a quick 10 minute assay used within the hospital environment.
This would mean that effective treatment can be administered to the patient much quicker.

TubeCentrifuge

 

Combining academic research with collaborations has given our world-class team the edge: our expertise in Sepsis research is growing fast.

We’re attracting interest from industrial partners as well as some very exciting grant-funded activities.

References:

Lab statistics

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Peptides synthesised

10

this year to-date

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Visitors Greeted

212

in the last month

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Assays completed

2700

this month

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New fungal species identified

0

This season

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